男性荷爾蒙受體 肝癌幫凶Male hormone receptor accomplices of liver cancer

男性荷爾蒙受體 肝癌幫凶 【陳惠惠】肝癌是台灣十大癌症頭號殺手，男性肝癌發生率又遠多於女性，長庚醫院研究團隊證實，男性荷爾蒙受體能加速肝癌細胞生長，形同肝癌的「幫凶」。動物試驗發現，從薑萃取出來的某種薑素衍生物可以破壞男性荷爾蒙受體，抑制肝癌細胞在老鼠體內生長。此研究結果已被美國胃腸道醫學會官方期刊所接受，並獲選主編精選。 長庚醫院消化核心實驗室主任葉昭廷指出，台灣人在Ｂ肝感染率上並無性別差異，但病房裡的肝癌患者，七、八成都是男性，真正原因過去並不清楚。 為了解開肝癌為何較常找上男性的謎團，長庚進行動物實驗，在十天大的老鼠身上注射鼠類肝臟致癌物二乙基亞硝胺，讓小老鼠罹患肝癌。有完整男性荷爾蒙受體的公鼠出現肝癌時間最早，發生率最高，其次為剔除肝臟男性荷爾蒙受體的公鼠，罹癌速度最慢且發生率最低的則是全身性剔除男性荷爾蒙受體的公鼠。 長庚醫院血液腫瘤科主治醫師徐正龍說，在未剔除荷爾蒙受體的公鼠身上施打薑素衍生物，可以破壞男性荷爾蒙受體，抑制肝癌細胞生長。 雖然動物試驗已看到初步效果，但徐正龍也指出，3公分以下的肝腫瘤裡，七成都看得到男性荷爾蒙受體表現，但在較大的肝腫瘤上，卻不再看得到此表現。也就是說，較大的肝腫瘤已打通其他路徑，不再「利用」荷爾蒙受體，因此，徐正龍說，未來治療上，較適用於剛動完手術後容易復發的肝癌病患。 2008-09-15 Male hormone receptor accomplices of liver cancer Chen Huihui [10] liver cancer in Taiwan is the number one cancer killer of men and the incidence of liver cancer far more than women, Chang Gung Memorial Hospital research team confirmed that the male hormone receptor can accelerate liver cancer cell growth, which is tantamount to liver cancer, "accomplice" . Animal tests found that ginger extracted from a certain Jiang derivatives can damage male hormone receptors, inhibit liver cancer cell growth in mice. The results of this study have been the United States of gastrointestinal medicine will be accepted by the official journals, and was elected editor of Highlights. Chang Gung Memorial Hospital to digest the core of the laboratory director Zhao Ting pointed out that the people of Taiwan in the infection rate of hepatitis B have no gender differences, but the liver cancer patients in the wards, 70% to 80% are men, the real cause of the past is not clear. In order to untie of liver cancer more frequently on men to find the mystery, Chang Gung animal experiments, 10 days in the mice injected large rodent carcinogens Diethylnitrosamine liver, small rats suffering from liver cancer. A complete male hormone receptors in the rat liver cancer in the earliest time, the highest rate, followed by the liver to remove the male hormone receptors in mice, Li Ai speed of the slowest rate and the lowest is systemic omissions male hormone receptor Of the mouse. Chang Gung Memorial Hospital blood cancer Dr. Xu Zhenglong said, in the absence of hormone receptor removed the mouse on the application of a ginger-derivatives, can damage male hormone receptors, inhibit liver cancer cell growth. Although animal experiments have seen initial results, but also pointed out that Xu Zhenglong, 3 cm below the liver tumor, seven male hormone receptor Chengdu to see performance, but in the larger liver tumors, has not seen this performance. In other words, the larger liver tumors has opened up other path, no longer "use the" hormone receptors, therefore, Xu Zhenglong, the next treatment, apply to more easily after just Dongwanshoushu recurrence of liver cancer patients. 2008-09-15 For more information, see World Journal News ePaper

瀏覽更多新聞，請看世界日報電子報 ePaper。