大突破 幹細胞可製紅血球Major breakthrough in stem cell system of red blood cells can be

大突破 幹細胞可製紅血球 【本報綜合報導】美國科學家日前表示，他們已開發出以人體胚胎幹細胞大量製造紅血球的技術。這項實驗結果意味，未來捐血可能不再有必要。不過專家指出，這種技術雖屬重大突破，但仍須經過一些關鍵性的改良，方可真正取代捐贈的血液。 伊利諾大學與明尼蘇達州羅契斯特梅約醫學中心的研究人員，在醫學期刊「血液」上發表實驗報告指出，他們以四個步驟將胚胎幹細胞轉化為紅血球細胞，攜氧量與正常血液相同。如果這項技術能夠實際運用，醫院與血庫將可以取得足量的各種人造血液，包括稀有的陰性AB型及可與各型血液相容的陰性Ｏ型血液，並在戰場、交通事故現場等場合發揮功能。 並未參與這項實驗的明尼蘇達大學幹細胞研究所副所長考夫曼表示，這項技術可使病患不再因為輸入別人捐的血而感染C型肝炎、愛滋病等疾病。他說：「這種技術很重要，因為感染的案例經常發生，而且捐血者越來越少。」 研究人員以一個培養皿的胚胎幹細胞製造一千億個紅血球細胞，足以注滿二、三個血液收集管。他們讓幹細胞展開初步的胚胎發展後，再讓它們接觸多種蛋白質，使其中一部分轉化成為紅血球細胞。擔任研究報告執筆人的「先進細胞技術公司」技術長藍沙表示，大約65%的細胞成熟後，脫去細胞核，出現紅血球細胞的甜甜圈外型。研究人員製造的血液包括陽性Ａ型、陰性Ａ型、陽性Ｂ型、陰性Ｂ型、陽性Ｏ型。 藍沙指出，在輸血過程中，紅血球細胞的使用頻率高於血液，換言之，這項新技術可望挽救無數的寶貴生命。 2008-09-10 Major breakthrough in stem cell system of red blood cells can be An integrated report - U.S. scientists have recently said that they have developed a human embryonic stem cells to mass-produce red blood cell technology. The results mean that the next blood donation may no longer be necessary. But experts pointed out that although this technology a major breakthrough, but we need a number of key improvements can really replace the donated blood. University of Illinois and Minnesota about Luoqi Si Te Mei Medical Center researchers in the medical journal "Blood," published reports that test, they will be four steps to embryonic stem cell cells into red blood cells, carrying the same volume and normal blood . If this technology can actually use, hospitals and blood banks will be able to get enough of artificial blood, including the rare AB-negative and can be compatible with various types of blood type O negative blood, and in the battlefield, the accident scene, and other occasions To work. The experiment did not take part in the University of Minnesota Stem Cell Institute, deputy director of Kaufman said that this technology will enable patients no longer because of the importation of others donated blood infected with hepatitis C, AIDS and other diseases. He said: "This technology is very important, because the frequent cases of infection, but blood donors less and less." Researchers with a Petri dish of embryonic stem cells created 100 billion of red blood cells, enough to fill two or three blood collection tube. They stem cells to start the initial development of embryos, let them contact with a variety of proteins, so that part of red blood cells into a cell. The author of the study "Advanced Cell Technology Company" technology officer of Blue Sha said that about 65 percent of the cells mature, take off his cell, red blood cells appear in the donut shape. The researchers, including manufacturers of blood type A positive and negative type A, type B-positive, B-negative, O-positive. Blue Sha pointed out that in the blood transfusion process, the red blood cells in the blood higher than the frequency of use, in other words, this new technology is expected to save countless lives. 2008-09-10 For more information, see World Journal News ePaper.

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