減少副作用 標靶治療 獵殺肺癌細胞Target to reduce the side effects of the treatment of lung cancer-killing cells

減少副作用 標靶治療 獵殺肺癌細胞 ●肺癌很難早期發現，一旦出現較明顯的症狀大多已是晚期，無法以手術切除，藥物治療非常關鍵，新一代的標靶藥物不斷推陳出新，使得對抗癌症又多了一項利器，也讓肺癌治療的瓶頸有重大突破。 命中 抑制癌細胞生長 中研院院士彭汪嘉康指出，所謂「標靶療法」是針對癌細胞之所以突變、增殖或擴散的機制，透過分子生物技術直接阻斷腫瘤細胞的生長與修復能力，或抑制腫瘤中的血管新生，從而防止腫瘤的轉移。她說，這種療法如同導彈直接命中目標，較傳統化療「散彈打鳥」方式，可達到有效殺死癌細胞，也大幅減少副作用。 阻斷 防腫瘤擴散轉移 目前，台灣核准臨床用於治療肺癌的標靶藥物，便是直接阻斷腫瘤生長訊息傳遞的小分子物質，也就是直接抑制上皮生長因子接受體(EGFR)酪胺酸激酉每的活性，便可壓抑腫瘤的生長與擴散。 台灣林口長庚醫院胸腔內科系主任郭漢彬表示，包括大腸直腸癌、肺癌和頭頸部癌症，都與EGFR的過度活化有關，因此，若能在細胞外直接阻斷EGFR，讓癌細胞趨於死亡。 肺腺癌 艾瑞莎效果較佳 這類上皮生長因子接受體抑制劑，有「艾瑞莎」（Iressa）和「得舒緩」（Tarceva）兩種，在台灣僅當第二線使用，且規定患者必須是先前接受化學治療，但仍局部惡化或轉移的肺腺癌病人。 不過，香港中文大學教授墨唐尼在第33屆歐洲腫瘤醫學會表示，雖然艾瑞莎和得舒緩的作用機轉類似，但根據最近在歐洲腫瘤醫學會所發表的一項IPSAA研究證實，艾瑞莎在臨床治療上，對於某些特定族群，包括上皮生長因子受體特定位置有突變者、東方女性、非抽菸者，以及屬於肺腺癌的患者，效果較佳。 整體療效 優於傳統化療 參與這項跨國研究的墨唐尼表示，對於肺腺癌病人而言，艾瑞莎不論在整體療效、生活品質的改善，比起傳統化療要佳。 郭漢彬說，得舒緩的適用對象，比較不受個別基因活性變化的影響，且對於肺腺癌及鱗狀細胞肺癌，不分男女性別，甚至抽菸者都有效果。 癌思停 突破一年存活瓶頸 前年10月美國食品暨藥物管理局也已批准「癌思停」（Avastin），用於治療肺癌。 台北榮總胸腔腫瘤科主任蔡俊明表示，醫界研究發現，腫瘤細胞為了存活壯大，會分泌血管新生因子，以便形成新的血管，以便輸送源源不絕的養分，因此血管越密集，腫瘤越惡性；而血管新生抑制劑便是直接切斷腫瘤的養分供應，餓死癌細胞。 蔡俊明說，過去肺癌病人一旦被醫師診斷晚期肺癌的病人，在傳統化療藥物治療，根本無法突破中位存活期一年的瓶頸，而癌思停卻是第一個打破存活期只有一年的籓籬。（詹建富） 2008-10-19 Target to reduce the side effects of the treatment of lung cancer-killing cells ● very difficult for the early detection of lung cancer, in the event of the more obvious symptoms is the most advanced, can not be removed by surgery, medication is key to target a new generation of drugs continues to introduce new measures to combat cancer makes more of a weapon, but also There are bottlenecks in the treatment of lung cancer a major breakthrough. Hit inhibit cancer cell growth Academia Sinica Jacqueline Whang-Peng pointed out that the so-called "target therapy" is the reason why cancer cells for mutations, or the spread of proliferation mechanism, molecular biological technology through direct blocking tumor cell growth and repair, or inhibition of tumor angiogenesis In order to prevent tumor metastasis. She said that such therapy as a direct missile hit the target, the more traditional chemotherapy, "Da Niao shot" approach can be achieved effectively kill cancer cells, but also significantly reduce the side effects. Blocking the spread of anti-tumor metastasis At present, Taiwan approved for the treatment of lung cancer clinical target drugs to block tumor growth is a direct message of the small molecule material, which is directly inhibit epidermal growth factor receptor (EGFR) tyrosine stimulated the enzyme activity, it is May suppress tumor growth and proliferation. Taiwan's Chang Gung Memorial Hospital Head of the Department of Thoracic Medicine, said Han-Pin Kuo, including colorectal cancer, lung cancer and head and neck cancer, with over-activation of EGFR, therefore, if the cell block foreign direct EGFR, so that cancer cells tend to death. Aretha effects of lung cancer better This type of epithelial growth factor receptor inhibitors, "Aretha" (Iressa) and the "have to ease" (Tarceva) are in Taiwan only if the second line, and must be provided for patients with prior chemotherapy, but Still deteriorating or partial transfer of lung cancer patients. However, the Chinese University of Hong Kong and Mexico, a professor at the Downey 33rd tumor of the European Medical Association said that while Aretha and ease of a mechanism similar to the role, but according to a recent medical oncology in Europe, published by a research IPSAA confirmed that the Al Aretha in the clinical treatment for certain ethnic groups, including the epithelial growth factor receptor mutation have a specific location, the Oriental women, non-smokers, as well as belonging to the lung cancer patients, and better results. The overall effect is better than traditional chemotherapy To participate in the study of cross-border Mexico, said Downey, for lung cancer patients, regardless of Aretha in the overall efficacy, quality of life improvement, compared with traditional chemotherapy to good. Han-Pin Kuo said that the object was to ease the application of relatively individual from the impact of changes in gene activity, and for lung adenocarcinoma and squamous cell lung cancer, regardless of gender, and even those who have the effect of smoking. Think of to stop cancer Breakthrough year survival bottleneck The year before last October the U.S. Food and Drug Administration also has approved the "cancer stop thinking" (Avastin), for the treatment of lung cancer. Taipei Veterans General Hospital, director of thoracic oncology Chun-Ming Tsai said that the medical community found that the survival of tumor cells to grow, secrete angiogenesis factor, in order to form new blood vessels, in order to transport an endless supply of nutrients, so the more intensive blood vessels, the more malignant tumor ; And angiogenesis inhibitors that cut off direct nutrient supply to tumors, cancer cells starve to death. Chun-Ming Tsai said that in the past, if lung cancer patients diagnosed with advanced lung cancer patients in the traditional chemotherapy treatment, could not break through the median survival time of the year bottleneck, and the cancer is to stop thinking of the first to break the one-year survival is only big winnow basket Lei. (Zhan Jian Fu) 2008-10-19 View more information, see the World Journal reported that e-ePaper

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多喝水 稀釋致癌物濃度Drink plenty of water diluted the concentration of carcinogenic

多喝水 稀釋致癌物濃度 泌尿科權威說一天至少2000cc 　專家提醒民眾多喝水，可減少泌尿道疾病。 水份攝取不足，會導致尿路結石。台灣泌尿科權威、輔仁大學醫學院院長江漢聲呼籲每人每天至少喝2000至3000毫升的水，不但可減少結石機率，還可稀釋致癌物質和病原濃度，降低感染可能。 江漢聲表示，若喝水量不足，尿液排出的量明顯下降。久而久之，尿液變得濃濁，既無法有效將泌尿系統中的細菌沖刷出去，且可能在泌尿系統中引發感染，造成發炎。 在外奔忙 隨時補充水分 他建議整天在外奔走勞動的人，出門時隨身攜帶水壺，隨時補充水份，常保泌尿道暢通無阻。 江漢聲說，多喝水其實並不難，只要把每天喝水量訂下來，比如2500或3000毫升，平均分散在早、中、晚的時段即可。早上可喝些牛奶或果汁；出門上班隨身帶個水壺，想喝就喝；中餐時多喝些湯；下午休息時，可泡杯咖咖，讓自己放鬆一下；下班回到家，再喝些果汁或泡壺茶。 暢快養生 水是不藥之王 「水是不藥之王。」江漢聲強調，既然人體大半成份是由水構成，就不難想像水對健康的重要性。就拿預防泌尿道疾病來說，多喝水可稀釋結石物質的結晶濃度，減少結石機率，也可稀釋致癌物質，不讓癌細胞有可乘之機。 江漢聲認為，水無好壞之分，只要煮過或處理過的乾淨水，都可拿來喝；每天攝取的水份，可以來自湯汁、果汁、白開水、茶或咖啡。 尿液顏色 可知水量充足否 要喝到多少才算足夠？江漢聲建議不妨從尿液顏色判知，如果尿液顏色深且混濁，就代表喝水量不足。唯有喝到尿液呈淡黃或淡綠且澄清透明，才能確定已喝夠水，不僅尿起來暢快無比，泌尿道結石、感染等疾病也不易上身。不過，他也提醒心衰竭、腎臟病及糖尿病等患者，喝水量應在醫師指導下嚴加控制，以免影響病情。 ／林進修 2008-09-21 Drink plenty of water diluted the concentration of carcinogenic Urology authority said at least one day 2000cc Experts advise people to drink plenty of water can reduce urinary tract diseases. Inadequate water intake can lead to urinary tract stones. Taiwan authority of Urology, Fu Jen Catholic University School of Medicine called on President Chiang Han-sheng per person per day to drink at least 2000-3000 ml of water, not only can reduce the risk of stones, but also dilute the concentration of carcinogenic substances and pathogens, could reduce infection. Chiang Han-sheng said that if the amount of water shortage, the discharge of urine volume decreased. Over time, become Nongzhuo urine, can not be effective in the urinary system of bacteria washed out, and may cause infection in the urinary tract, causing inflammation. Bustle out at any time to add water He suggested that all day running out of the labor force, to carry water bottles when they go out at any time to add water, regular security urinary tract smooth. Yeung said Jianghan, drink plenty of water would not be difficult as long as the volume of water per day once they are laid down, such as 2500 or 3000 ml, the spread in the early, middle and late periods can be. In the morning to drink milk or fruit juice; go to work carrying a water bottle, drink to drink; drink some Chinese food at soup; rest in the afternoon when the bubble coffee cup coffee, relax himself; home from work, Zaihe Some fruit juice or bubble tea pot. Water is not fun at all health drug king "Water is not the king of drugs." Chiang Han-sheng stressed that since most of the components of the human body is constituted by the water, it is not hard to imagine the importance of water to health. Take the prevention of urinary tract disease, drink plenty of water can dilute the concentration of the crystallization of stone material to reduce the risk of stones, but also dilute the cancer-causing substances from cancer cells get their chances. Chiang Han-sheng of the view that no water good or bad, as long as cooked or processed clean water, can be used as a drink; daily intake of water, juice from the can, fruit juice, water, tea or coffee. Urine color know whether adequate water To drink how much is enough? Chiang Han-sheng recommendations from the urine color may be sentenced to know if the urine color turbid and deep, on behalf of the volume of water shortage. Only drink urine Chengdan light green or yellow and transparent clarification in order to make sure they drink enough water, not only great fun with urine, urinary tract stones, also infected with diseases such as upper body is not easy. However, he also reminded heart failure, kidney disease and diabetes patients, amount of water should be strictly controlled under the guidance of a doctor, so as not to affect the disease. / Lin education 2008-09-21 View more information, see the World Journal reported that e-ePaper

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炸薯條吃太多 易致癌Easy to eat too many fries cause cancer

炸薯條吃太多 易致癌 　德國專家對多種油炸薯條和薯片的檢測發現，吃多了容易在人體累積致癌物質。 【中新網】科技日報報導，德國慕尼黑技術大學的毒理學專家在對多種油炸薯條和薯片的檢測中首次發現，這些油炸食品中含有微量致癌的甘油胺(Glycidamid)物質，吃多了容易在人體中積累並誘發癌症。 之前人們只知道油炸薯類食品中含有不利於健康的丙烯胺物質，現在德國科學家發現甘油胺比丙烯胺更具有危害性。參與研究的德國凱薩斯勞滕大學科學家還在哺乳動物的細胞中發現，少量的甘油胺就能在動物體內形成癌症腫瘤，這一研究結果已刊登在國際《農業和食品化學》雜誌上。 慕尼黑大學專家在油炸薯條和薯片中發現的甘油胺劑量在每公斤0.3微克至1.5微克，同樣量薯條和薯片中的丙烯胺為300微克至600微克，而丙烯胺在人體肝臟中又可以部分轉化為甘油胺。目前專家還沒有確認，究竟多少劑量的甘油胺會導致癌症，專家只是建議少吃油炸薯條和薯片。 和丙烯胺一樣，甘油胺主要是在碳水化合物食品的高溫加工過程中產生的，通常在120℃（248℉）以上出現，高於180攝氏度時有害物質急劇增加，專家建議說，油炸薯條時，溫度控制在175℃（347℉）以下，這樣產生的甘油胺物質較少。 2008-09-10 Easy to eat too many fries cause cancer German experts on a variety of oil potato chips and crisps the test found that eating more easily accumulate in human carcinogen. [中新网- Science and Technology Daily reported that the Technical University of Munich, Germany, toxicology experts in a variety of oil potato chips and crisps in the first test found that these fried foods containing traces of carcinogens in the glycerol amines (Glycidamid) Material, eat more easily accumulate in the body and induced cancer. Before people only know that fried potato food products contain not conducive to the health of acrylamide material, German scientists found that glycerin amines than acrylamide in more danger. Participated in the study of the German Caesar Silao Teng University scientists also found in mammalian cells, small amounts of glycerine amine can form of cancer in animals cancer, the study results were published in the international "Agriculture and Food Chemistry" Magazine. University of Munich experts in the oil potato chips and crisps were found in the glycerol amine dose of 0.3 micrograms per kilogram to 1.5 micrograms, the same volume of French fries and potato chips in the acrylamide is 300 micrograms to 600 micrograms, and Acrylamide in human liver can be transformed into part of glycerol amines. Experts have not yet confirmed how many doses of glycerin amines would lead to cancer, the experts recommended only eat oil potato chips and crisps. And acrylamide, glycerol amine mainly in carbohydrate foods high temperature in the process, usually in the 120 ℃ (248 ℉) over there, higher than 180 degrees Celsius, a sharp increase in harmful substances, the experts suggested that the fried potato Of the time, temperature control in the 175 ℃ (347 ℉) below, the glycerol amines such substances less. 2008-09-10 For more information, see World Journal News ePaper.

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鼻咽癌病毒 也會致肺癌NPC will also induced lung cancer virus

鼻咽癌病毒 也會致肺癌 【施靜茹】鼻咽癌患者身上常見的第四型人類 疹病毒（EB病毒），竟也會導致肺癌，台北榮民總醫院胸腔腫瘤科醫師已發現病例，並將其發表在醫學期刊。 台北榮民總醫院胸腔腫瘤科主任蔡俊明說，一名51歲男性來就診，患者做健康檢查照胸部X光，發現右下肺葉疑似長了腫瘤，進一步做電腦斷層後確診，特別的是，患者只有輕微的糖尿病，而且不吸菸，過去也沒有發生嚴重疾病。 這名男性的肺腫瘤沒有遠處轉移，醫院趕緊為他安排手術切除，病理切片結果，確定為原發性類淋巴上皮癌，屬於肺癌的一種，醫師進一步在患者的腫瘤組織裡，找到了第四型人類 疹病毒。 蔡俊明說，肺癌大致分為肺小細胞癌和非小細胞肺癌，後者又分肺鱗狀細胞癌、肺腺癌、肺大細胸癌等三種，原發性類淋巴上皮癌較不常見，世界衛生組織在1982年公布的肺癌分類上，仍未將此一腫瘤列入。 蔡俊明表示，第四型人類 疹病毒常見中國南方及台灣病患身上，特別是鼻咽癌患者，但在肺癌患者身上發現，的確不尋常，已將此病例發表在「胸腔醫學」期刊。 該期刊四年前也曾接受另一名醫師投稿，報告一名46歲女性，偶爾會咳血已超過一年，檢查發現她左下肺葉有腫瘤，後來一樣接受手術切除治療。 蔡俊明指出，原發性類淋巴上皮癌患者，大多透過開刀才確診，由於它沒那麼惡性，五年存活率比一般肺癌好，復發率低，患者接受化療的效果也不錯。 長期吸菸或吸入有害氣體，都可能造成肺癌，也有人是因為本身有致癌基因的遺傳，或免疫系統較弱，年過四十歲的人，最好每年接受一次胸部X光檢查。 2008-09-10 NPC will also induced lung cancer virus [Shi Jing-Ru was common in patients with nasopharyngeal cancer - the fourth-human measles virus (EB virus), has also lead to lung cancer, Taipei Veterans General Hospital thoracic oncology physicians have found cases, and published in medical journals. Taipei Veterans General Hospital, director of thoracic oncology Chun-Ming Tsai, a 51-year-old male to medical, health checks as do patients with chest X-ray, found the right lower lobe of the suspected tumor, and further CT scan done after the diagnosis, in particular that the Only patients with mild diabetes, and non-smokers, there was no serious illness over the past also. The men's lung cancer not distant metastasis, the hospital quickly arranged for his removal, pathology biopsy results, identified as primary category lymph cell carcinoma, a kind of lung cancer, doctors further in patients with tumors, found the first Four of human measles virus. Chun-Ming Tsai said that lung cancer is broadly divided into small cell lung cancer and non-small cell lung cancer, which in turn sub-squamous cell lung cancer, lung cancer, lung cancer, three small chest, the primary category lymph cell carcinoma less common, The World Health Organization announced in the 1982 classification of lung cancer, the tumor has not yet included in this one. Chun-Ming Tsai said that fourth-human measles virus common in southern China and Taiwan on patients, especially patients with nasopharyngeal carcinoma, but was found in patients with lung cancer, it is not unusual, this case has been published in the "medicine chest" Series. The journals have accepted four years ago, another doctor articles, reports a 46-year-old female, occasionally hemoptysis has more than a year, inspection revealed that she has left lower lobe tumor, and later the same surgery for the treatment. Chun-Ming Tsai pointed out that the primary category lymph cell carcinoma patients, most diagnosed only through surgery, because it not as vicious, five-year survival rate of lung cancer than the general good, the low rate of relapse, patients undergoing chemotherapy effect is not bad. Long-term smoking or inhalation of harmful gases may cause lung cancer, it was also because of its own genetic cancer gene, or weak immune system, in a 40-year-old, the best annual accept a chest X-rays. 2008-09-10 For more information, see World Journal News ePaper

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癌患八成死於併發症

癌患八成死於併發症 【新華網】日前在天津召開的「中國首屆腫瘤併發症介入治療學術研討會」上，專家指出，約有80％－90％的病人死於腫瘤併發症，而非腫瘤本身。與會專家提出，腫瘤併發症應引起人們廣泛關注，在腫瘤治療過程中應該重視併發症對患者生命的影響，提高其生活質量。 據專家表示，腫瘤併發症是指在自然病程發展過程中，腫瘤發生侵犯、轉移到某些臟器，或者是在治療過程中因手術、放化療而難以避免所產生的一係列綜合病症，某些腫瘤併發症是患者首發症狀。 腫瘤併發症對患者的生命、生活質量均會產生不同程度的影響，嚴重的併發症是腫瘤患者的主要死因。 中國抗癌協會介入專業委員會副主任委員、天津市腫瘤醫院介入腫瘤治療科主任郭志教授指出，腫瘤併發症的診治相對於實體性腫瘤的治療，在醫療界還沒有引起足夠的重視。介入治療作為一種新興的治療手段，以其微創、高效、低毒等特點逐漸被患者接受，特別是在腫瘤併發症治療方面優勢更為突出。 此外，介入治療在挽救患者生命、為癌症晚期或無法手術的患者獲取手術機會等方面也可起到重要作用。 郭志強調，在全力針對腫瘤的治療過程中，切不可忽視腫瘤併發症的治療。腫瘤科醫生應該加強學科之間交流、豐富腫瘤綜合治療內容，在挽救患者生命的同時重視提高其生活質量，提高總體治療水平，是腫瘤治療的現實問題。 2007-12-26

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子 宮 頸 癌或 睾 丸 癌兩 類 癌 症 者 離 婚 率 高

兩 類 癌 症 者 離 婚 率 高 患 子 宮 頸 癌 或 睾 丸 癌 的 病 人 ， 較 其 他 癌 症 患 者 容 易 離 婚 收 場 。 挪 威 一 項 研 究 ， 了 解 癌 症 病 人 與 健 康 人 士 離 婚 比 率 ， 共 分 析 了 21 萬 名 癌 症 患 者 及 健 康 夫 婦 。 結 果 顯 示 ， 患 子 宮 頸 癌 的 女 性 於 20 歲 時 其 離 婚 率 逾 70% ， 患 有 睾 丸 癌 的 20 歲 男 性 離 婚 率 則 達 34% ， 離 婚 率 不 單 較 健 康 人 士 高 ， 也 較 患 上 其 他 癌 症 的 患 者 為 高 。 研 究 人 員 估 計 是 因 為 這 兩 類 癌 症 減 少 了 性 行 為 的 次 數 ， 破 壞 夫 婦 關 係 。

28-09-2007